While the process is designed to be surgical, there are "traps" that can lead to unintended data loss or system issues: Does Windows Installation Media Wipe a Disk Clean
Before you start that clean install to fix your PC:
The short answer is: It is exclusive to the drive you select during the setup process.
If you clean install Windows onto and delete its partitions during setup → only Drive C is wiped . Drives D and E keep all their data.