: For a standard installation on Windows 7 64-bit, MATLAB R2021b was the final release to officially support Windows 7.
MATLAB isn't natively portable, meaning it's designed to be installed on a system with specific registry and file system modifications. However, there are approaches to make MATLAB more portable: matlab portable windows 7 64 bit
Short recommendation
MATLAB uses a robust licensing system (FlexNet or Online Licensing). Each session checks in with a license server or a locally stored license file tied to specific hardware. Running from a USB drive means the hardware ID changes from one host PC to another—triggering an activation failure. : For a standard installation on Windows 7