Set in 2092, the world has achieved immortality. Nemo Nobody (Jared Leto), at 118 years old, is the last remaining mortal. On his deathbed, he recounts his life to a journalist, but his memories are a tangled web of parallel realities that contradict one another.
The film is set in a dystopian future where humanity has achieved immortality through "quasi-immortality" treatments. Nemo Nobody (Jared Leto) is the last mortal man on Earth, 118 years old and preparing for death. As a psychiatrist interviews him to record his memories, Nemo recounts his life. However, he tells it in contradictory ways.