Juq-063 _top_ Jun 2026

KOR antagonism directly tackles the underlying these disorders, offering a mechanistic advantage.

| Aspect | What the Paper Shows | Why It Stands Out | |--------|----------------------|-------------------| | | JUQ‑063 binds the ATP‑binding pocket of PI3K‑α (IC₅₀ = 23 nM) and inserts into the outer mitochondrial membrane, altering Drp1‑mediated fission. | Demonstrates that a single scaffold can simultaneously hit a canonical kinase and a non‑protein target—a rarity that sparks drug‑design discussions. | | Structural biology | Co‑crystal structure of JUQ‑063 with PI3K‑α at 2.1 Å resolution (PDB 6Z8L) plus cryo‑EM maps of mitochondria treated with the compound. | Provides a visual, atom‑level explanation for the dual activity, enabling rational analog design. | | In‑vivo efficacy | Orthotopic glioblastoma mouse model: 80 % tumor‑growth inhibition after 21 days of daily 10 mg kg⁻¹ oral dosing; median survival extended from 28 days (control) to >60 days. | Shows translational relevance beyond cell culture, a step many early‑stage inhibitors never reach. | | Safety profile | No significant weight loss, liver enzyme elevation, or off‑target cardiotoxicity in a 28‑day repeat‑dose toxicity study (n = 5 per sex). | Suggests a therapeutic window that justifies further pre‑clinical development. | | Chemical novelty | First example of a quinazolinone core bearing a 1,3‑diazole side chain that enables mitochondrial membrane insertion without a classic lipophilic tail. | Opens a new SAR (structure‑activity relationship) space for “mitochondria‑targeted kinase inhibitors.” | JUQ-063

Fast for 16 hours and eat during an 8-hour window (e.g., 12 PM to 8 PM). This is the most popular entry-level approach. | | Structural biology | Co‑crystal structure of

A second, more mathematically inclined reading treats JUQ‑063 as a shorthand for a family of quantum error‑correcting codes. In the nomenclature of stabilizer codes, a string like “[[n,k,d]]” describes the number of physical qubits ( n ), logical qubits ( k ), and code distance ( d ). The “JUQ” prefix could denote a ust‑in‑time U niversal Q uasi‑code, a hybrid that blends features of surface codes (high threshold, locality) and concatenated codes (flexibility). The number “063” might indicate the code’s parameters (e.g., n = 6, k = 3, d = 3 ), a compact configuration that offers a surprisingly high logical fidelity for a modest qubit overhead. | Shows translational relevance beyond cell culture, a