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: Briefly disable your antivirus or VPN on both ends to see if the connection establishes. 3. Network and Server Verification

Proxy servers often interfere with direct desk-to-desk connections. Go to > Network & Internet > Proxy . Toggle Automatically detect settings to ON . Toggle Use a proxy server to OFF . 5. Flush Your DNS Cache

Connecting to the wrong IP address or a port where AnyDesk is not listening will trigger this refusal.